The AFP test involves taking a blood sample. Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand.

Usually, there is little pain associated with a blood drawing. When the needle is inserted to draw blood, some people feel moderate discomfort, while others feel only a prick or stinging sensation.

There are few risks with this test:

• Excessive bleeding.
• Fainting or feeling lightheaded.
• Hematoma (blood accumulating under the skin).
• Infection (a slight risk any time the skin is broken).
• Multiple punctures to locate veins.